INTRODUCTION
Triple X syndrome occurs in females as a result
of one or more additional X chromosomes. Instead
of the usual female karyotype 46XX, the karyotype
is 47XXX or more rare 48XXXX or 49XXXXX. Affected
females are physically normal
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ANTENATAL
Except for the severe and rare expression of this
syndrome with karyotype 49XXXXX, most cases of triple
X syndrome have no distinguishing features on ultrasound.
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POSTNATAL
Girls with triple X syndrome have a normal phenotype
but are taller than average. Puberty and fertility
are normal but premature ovarian failure can occur.
Educational problems are more common than with other
sex chromosome anomalies. Average IQs are lower,
there is some impairment of cognitive ability, and
development of speech may be delayed. Individuals
with karyotypes 48XXXX and 49XXXXX have more severe
physical characteristics such as microcephaly, mental
retardation, and dysmorphic facial features
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WEST MIDLANDS
DATA
To be added
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